1 keywords

CATH Domain 4gmxA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.300 P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family GTP-binding nuclear protein Ran

Enzyme Information

UniProtKB Entries (2)

P62826
RAN_HUMAN
Homo sapiens
GTP-binding nuclear protein Ran
P30822
XPO1_YEAST
Saccharomyces cerevisiae S288C
Exportin-1

PDB Structure

PDB 4GMX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Lapalombella, R., Sun, Q., Williams, K., Tangeman, L., Jha, S., Zhong, Y., Goettl, V., Mahoney, E., Berglund, C., Gupta, S., Farmer, A., Mani, R., Johnson, A.J., Lucas, D., Mo, X., Daelemans, D., Sandanayaka, V., Shechter, S., McCauley, D., Shacham, S., Kauffman, M., Chook, Y.M., Byrd, J.C.
Blood