CATH Domain 4gl2B03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1320	phosphoenolpyruvate carboxylase, domain 3
	1.20.1320.30

Domain Context

CATH Clusters

Superfamily	1.20.1320.30
Functional Family	Interferon-induced with helicase C domain 1

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt Q9BYX4

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q9BYX4

IFIH1_HUMAN

Homo sapiens

Interferon-induced helicase C domain-containing protein 1

PDB Structure

PDB	4GL2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5. Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Chu, F., Walz, T., Hur, S. Cell(Cambridge,Mass.)