CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.340 | Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain |
| Functional Family | Cytosolic 5-nucleotidase 3-like |
Enzyme Information
| 3.1.3.5 |
5'-nucleotidase.
based on mapping to UniProt Q9D020
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
-!- Wide specificity for 5'-nucleotides.
|
| 3.1.3.91 |
7-methylguanosine nucleotidase.
based on mapping to UniProt Q9D020
(1) N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate. (2) CMP + H(2)O = cytidine + phosphate.
-!- The enzyme also has low activity with N(7)-methyl-GDP, producing N(7)-methyl-GMP. -!- Does not accept AMP or GMP, and has low activity with UMP.
|
UniProtKB Entries (1)
| Q9D020 |
5NT3A_MOUSE
Mus musculus
Cytosolic 5'-nucleotidase 3A
|
PDB Structure
| PDB | 4FE3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis of Substrate Specificity and Selectivity of Murine Cytosolic 5'-Nucleotidase III.
J.Mol.Biol.
|