CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Peroxisomal 2,4-dienoyl-CoA reductase |
Enzyme Information
| 1.3.1.34 |
2,4-dienoyl-CoA reductase (NADPH).
based on mapping to UniProt Q9NUI1
Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5- tetradehydroacyl-CoA + NADPH.
-!- Best substrates for reduction contain a 2,4-diene structure with chain length C(8) or C(10).
|
UniProtKB Entries (1)
| Q9NUI1 |
DECR2_HUMAN
Homo sapiens
Peroxisomal 2,4-dienoyl-CoA reductase
|
PDB Structure
| PDB | 4FC6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids
J.Biol.Chem.
|
