CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.21 | Purple Acid Phosphatase; chain A, domain 2 |
|
3.60.21.10 | Metallo-dependent phosphatases |
Domain Context
CATH Clusters
| Superfamily | 3.60.21.10 |
| Functional Family | Serine/threonine-protein phosphatase |
Enzyme Information
| 3.1.3.16 |
Protein-serine/threonine phosphatase.
based on mapping to UniProt Q08209
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
|
UniProtKB Entries (2)
| Q08209 |
PP2BA_HUMAN
Homo sapiens
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
|
| O36972 |
IKBL_ASFM2
African swine fever virus Malawi LIL 20/1
IkB-like protein
|
PDB Structure
| PDB | 4F0Z |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.
Plos Biol.
|
