CATH Domain 4einA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Possible thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P07607

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_MOUSE

Mus musculus

Thymidylate synthase

PDB Structure

PDB	4EIN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate Dowiercial, A., Jarmula, A., Rypniewski, W.R., Wilk, P., Kierdaszuk, B., Rode, W. PTERIDINES