CATH Domain 4dx6B01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1640	Multidrug efflux transporter AcrB transmembrane fold
	1.20.1640.10	Multidrug efflux transporter AcrB transmembrane domain

Domain Context

CATH Clusters

Superfamily	Multidrug efflux transporter AcrB transmembrane domain
Functional Family	Efflux pump membrane transporter

Enzyme Information

UniProtKB Entries (1)

ACRB_ECOLI

Escherichia coli K-12

Multidrug efflux pump subunit AcrB

PDB Structure

PDB	4DX6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Eicher, T., Cha, H.J., Seeger, M.A., Brandstatter, L., El-Delik, J., Bohnert, J.A., Kern, W.V., Verrey, F., Grutter, M.G., Diederichs, K., Pos, K.M. Proc.Natl.Acad.Sci.USA