CATH Domain 4dotA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1720	endopeptidase fold (from Nostoc punctiforme)
	3.90.1720.10	endopeptidase domain like (from Nostoc punctiforme)

Domain Context

CATH Clusters

Superfamily	endopeptidase domain like (from Nostoc punctiforme)
Functional Family	HRAS like suppressor 2

Enzyme Information

3.1.1.4	Phospholipase A(2). based on mapping to UniProt P53816 Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. -!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
2.3.1.-	Transferring groups other than amino-acyl groups. based on mapping to UniProt P53816
3.1.1.32	Phospholipase A(1). based on mapping to UniProt P53816 Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate. -!- Has a much broader specificity than EC 3.1.1.4.

UniProtKB Entries (1)

PLAT3_HUMAN

Homo sapiens

Phospholipase A and acyltransferase 3

PDB Structure

PDB	4DOT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins. Golczak, M., Kiser, P.D., Sears, A.E., Lodowski, D.T., Blaner, W.S., Palczewski, K. J.Biol.Chem.