1 keywords

CATH Domain 4crlA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.510 Transferase(Phosphotransferase); domain 1
Homologous Superfamily 1.10.510.10 Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cyclin-dependent kinase 8 isoform X1

Enzyme Information

2.7.11.23
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt P49336
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.
2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P49336
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24863
CCNC_HUMAN
Homo sapiens
Cyclin-C

PDB Structure

PDB 4CRL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml
Pelish, H.E., Liau, B.B., Nitulescu, I.I., Tangpeerachaikul, A., Poss, Z.C., Da Silva, D.H., Caruso, B.T., Arefolov, A., Fadeyi, O., Christie, A.L., Du, K., Banka, D., Schneider, E.V., Jestel, A., Zou, G., Si, C., Ebmeier, C.C., Bronson, R.T., Krivtsov, A.V., Myers, A.G., Kohl, N.E., Kung, A.L., Armstrong, S.A., Lemieux, M.E., Taatjes, D.J., Shair, M.D.
Nature