CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Estradiol 17-beta-dehydrogenase 8 |
Enzyme Information
| 1.1.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q92506
|
| 1.1.1.62 |
17-beta-estradiol 17-dehydrogenase.
based on mapping to UniProt Q92506
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
-!- The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids. -!- The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270. -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
|
| 1.1.1.239 |
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)).
based on mapping to UniProt Q92506
Testosterone + NAD(+) = androstenedione + NADH.
-!- Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids. -!- Different from EC 1.1.1.50 or EC 1.1.1.213. -!- Formerly EC 1.1.1.63.
|
UniProtKB Entries (1)
| Q92506 |
DHB8_HUMAN
Homo sapiens
Estradiol 17-beta-dehydrogenase 8
|
PDB Structure
| PDB | 4CQL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase.
Nat.Commun.
|