CATH Domain 4cooA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1100

Domain Context

CATH Clusters

Superfamily	3.40.50.1100
Functional Family	Cystathionine beta-synthase

Enzyme Information

4.2.1.22

Cystathionine beta-synthase.

based on mapping to UniProt P35520

L-serine + L-homocysteine = L-cystathionine + H(2)O.

-!- A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans. -!- Formerly EC 4.2.1.21.

UniProtKB Entries (1)

P35520

CBS_HUMAN

Homo sapiens

Cystathionine beta-synthase

PDB Structure

PDB	4COO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation. Mccorvie, T.J., Kopec, J., Hyung, S., Fitzpatrick, F., Feng, X., Termine, D., Strain-Damerell, C., Vollmar, M., Fleming, J., Janz, J.M., Bulawa, C., Yue, W.W. J.Biol.Chem.