CATH Domain 4cmhB02

Superfamily	Immunoglobulins
Functional Family	Immunoglobulin heavy constant gamma 1

CD38_HUMAN

Homo sapiens

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

PDB	4CMH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies. Deckert, J., Wetzel, M.C., Bartle, L.M., Skaletskaya, A., Goldmacher, V.S., Vallee, F., Zhou-Liu, Q., Ferrari, P., Pouzieux, S., Lahoute, C., Dumontet, C., Plesa, A., Chiron, M., Lejeune, P., Chittenden, T., Park, P.U., Blanc, V. Clin. Cancer Res.