1 keywords

CATH Domain 4c5cA03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1490 Dna Ligase; domain 1
Homologous Superfamily 3.30.1490.20 ATP-grasp fold, A domain

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, A domain
Functional Family D-alanine--D-alanine ligase

Enzyme Information

6.3.2.4
D-alanine--D-alanine ligase.
based on mapping to UniProt P07862
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
-!- Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.

UniProtKB Entries (1)

P07862
DDLB_ECOLI
Escherichia coli K-12
D-alanine--D-alanine ligase B

PDB Structure

PDB 4C5C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.
Batson, S., de Chiara, C., Majce, V., Lloyd, A.J., Gobec, S., Rea, D., Fulop, V., Thoroughgood, C.W., Simmons, K.J., Dowson, C.G., Fishwick, C.W.G., de Carvalho, L.P.S., Roper, D.I.
Nat Commun