CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.630 | Aminopeptidase |
|
3.40.630.170 |
Domain Context
CATH Clusters
| Superfamily | 3.40.630.170 |
| Functional Family | Glycylpeptide N-tetradecanoyltransferase |
Enzyme Information
| 2.3.1.97 |
Glycylpeptide N-tetradecanoyltransferase.
based on mapping to UniProt P30419
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal- N-tetradecanoylglycyl-[protein].
-!- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. -!- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. -!- The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.
|
UniProtKB Entries (1)
| P30419 |
NMT1_HUMAN
Homo sapiens
Glycylpeptide N-tetradecanoyltransferase 1
|
PDB Structure
| PDB | 4C2Z |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Chemical Proteomics Defines the Mammalian N- Myristoylated Proteome in Live Cells Global Profiling of Co- and Post-Translationally N-Myristoylated Proteomes in Human Cells.
Nat.Commun.
|