CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1600 | SIR2/SIRT2 'Small Domain' |
|
3.30.1600.10 | SIR2/SIRT2 'Small Domain' |
Domain Context
CATH Clusters
| Superfamily | SIR2/SIRT2 'Small Domain' |
| Functional Family | NAD-dependent deacetylase sirtuin-3, mitochondrial |
Enzyme Information
| 3.5.1.- |
In linear amides.
based on mapping to UniProt Q9NTG7
|
UniProtKB Entries (1)
| Q9NTG7 |
SIR3_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
|
PDB Structure
| PDB | 4BVG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.
Proc. Natl. Acad. Sci. U.S.A.
|