1 keywords

CATH Domain 4bhiA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.60 4-Layer Sandwich
Topology 3.60.130 Double-stranded beta-helix
Homologous Superfamily 3.60.130.10 Clavaminate synthase-like

Domain Context

CATH Clusters

Superfamily Clavaminate synthase-like
Functional Family Gamma-butyrobetaine dioxygenase

Enzyme Information

1.14.11.1
Gamma-butyrobetaine dioxygenase.
based on mapping to UniProt O75936
4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) = 3-hydroxy-4- trimethylammoniobutanoate + succinate + CO(2).

UniProtKB Entries (1)

O75936
BODG_HUMAN
Homo sapiens
Gamma-butyrobetaine dioxygenase

PDB Structure

PDB 4BHI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
Tars, K., Leitans, J., Kazaks, A., Zelencova, D., Liepinsh, E., Kuka, J., Makrecka, M., Lola, D., Andrianovs, V., Gustina, D., Grinberga, S., Liepinsh, E., Kalvinsh, I., Dambrova, M., Loza, E., Pugovics, O.
J.Med.Chem.