CATH Domain 4av1D00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1740	first zn-finger domain of poly(adp-ribose) polymerase-1
	3.30.1740.10	Zinc finger, PARP-type

Domain Context

CATH Clusters

Superfamily	Zinc finger, PARP-type
Functional Family

Enzyme Information

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt P09874

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt P09874

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

P09874

PARP1_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase 1

PDB Structure

PDB	4AV1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks Ali, A.A.E., Timinszky, G., Arribas-Bosacoma, R., Kozlowski, M., Hassa, P.O., Hassler, M., Ladurner, A.G., Pearl, L.H., Oliver, A.W. Nat.Struct.Mol.Biol.