CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Acetylserotonin O-methyltransferase |
Enzyme Information
| 2.1.1.4 |
Acetylserotonin O-methyltransferase.
based on mapping to UniProt P46597
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
-!- Some other hydroxyindoles also act as acceptor, more slowly.
|
UniProtKB Entries (1)
| P46597 |
ASMT_HUMAN
Homo sapiens
Acetylserotonin O-methyltransferase
|
PDB Structure
| PDB | 4A6D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.
J.Pineal Res.
|
