CATH Domain 4a1oB02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.140	Cytidine Deaminase; domain 2
	3.40.140.20	AICAR transformylase, duplication domain

Domain Context

CATH Clusters

Superfamily	3.40.140.20
Functional Family

Enzyme Information

3.5.4.10	IMP cyclohydrolase. based on mapping to UniProt P9WHM7 IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3	Phosphoribosylaminoimidazolecarboxamide formyltransferase. based on mapping to UniProt P9WHM7 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

PUR9_MYCTU

Mycobacterium tuberculosis H37Rv

Bifunctional purine biosynthesis protein PurH

PDB Structure

PDB	4A1O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Analyses of a Purine Biosynthetic Enzyme from Mycobacterium Tuberculosis Reveal a Novel Bound Nucleotide. Le Nours, J., Bulloch, E.M.M., Zhang, Z., Greenwood, D.R., Middleditch, M.J., Dickson, J.M.J., Baker, E.N. J.Biol.Chem.