CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.3
Cysteine transaminase.
based on mapping to UniProt P17174
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
2.6.1.1
Aspartate transaminase.
based on mapping to UniProt P17174
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.

UniProtKB Entries (1)

P17174
AATC_HUMAN
Homo sapiens
Aspartate aminotransferase, cytoplasmic

PDB Structure

PDB 3WZF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Recombinant expression, purification and Preliminary crystallographic studies of human cytoplasmic aspartate aminotransferase
Jiang, X., Chang, H., Zhou, Y., Chen, L., Yang, Q.
To be Published