CATH Domain 3vd4D04

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Beta-galactosidase

Enzyme Information

3.2.1.23

Beta-galactosidase.

based on mapping to UniProt P00722

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D- galactosides.

-!- Some enzymes in this group hydrolyze alpha-L-arabinosides; some animal enzymes also hydrolyze beta-D-fucosides and beta-D-glucosides (cf. EC 3.2.1.108).

UniProtKB Entries (1)

P00722

BGAL_ECOLI

Escherichia coli K-12

Beta-galactosidase

PDB Structure

PDB	3VD4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., Huber, R.E. Arch.Biochem.Biophys.