CATH Domain 3vc4A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Serine/threonine-protein kinase pim-1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P11309

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P11309

PIM1_HUMAN

Homo sapiens

Serine/threonine-protein kinase pim-1

PDB Structure

PDB	3VC4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. Good, A.C., Liu, J., Hirth, B., Asmussen, G., Xiang, Y., Biemann, H.P., Bishop, K.A., Fremgen, T., Fitzgerald, M., Gladysheva, T., Jain, A., Jancsics, K., Metz, M., Papoulis, A., Skerlj, R., Stepp, J.D., Wei, R.R. J.Med.Chem.