CATH Domain 3v7tD02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Tryptase gamma 1

Enzyme Information

3.4.21.59

Tryptase.

based on mapping to UniProt P20231

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.

-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P20231

TRYB2_HUMAN

Homo sapiens

Tryptase beta-2

PDB Structure

PDB	3V7T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity Liang, G., Choi-Sledeski, Y.M., Shum, P., Chen, X., Poli, G.B., Kumar, V., Minnich, A., Wang, Q., Tsay, J., Sides, K., Kang, J., Zhang, Y. Bioorg.Med.Chem.Lett.