CATH Classification

Domain Context

CATH Clusters

Superfamily Inositol-pentakisphosphate 2-kinase, N-lobe
Functional Family Inositol-pentakisphosphate 2-kinase

Enzyme Information

2.7.1.158
Inositol-pentakisphosphate 2-kinase.
based on mapping to UniProt Q93YN9
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.
-!- The enzyme can also use Ins(1,4,5,6)P(4) and Ins(1,4,5)P(3) as substrate. -!- Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolyzed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment.

UniProtKB Entries (1)

Q93YN9
IPPK_ARATH
Arabidopsis thaliana
Inositol-pentakisphosphate 2-kinase

PDB Structure

PDB 3UDT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inositol phosphate-induced stabilization of inositol 1,3,4,5,6-pentakisphosphate 2-kinase and its role in substrate specificity.
Gosein, V., Leung, T.F., Krajden, O., Miller, G.J.
Protein Sci.