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1 keywords

CATH Domain 3tftA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.1150 Aspartate Aminotransferase, domain 1
Homologous Superfamily 3.90.1150.10 Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Enzyme Information

2.6.1.62
Adenosylmethionine--8-amino-7-oxononanoate transaminase.
based on mapping to UniProt P9WQ81
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4- methylthio-2-oxobutanoate + 7,8-diaminononanoate.
-!- S-adenosylhomocysteine can also act as donor.

UniProtKB Entries (1)

P9WQ81
BIOA_MYCTU
Mycobacterium tuberculosis H37Rv
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

PDB Structure

PDB 3TFT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis.
Shi, C., Geders, T.W., Park, S.W., Wilson, D.J., Boshoff, H.I., Abayomi, O., Barry, C.E., Schnappinger, D., Finzel, B.C., Aldrich, C.C.
J.Am.Chem.Soc.
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