CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.200 | Peptidase S8/S53 domain |
Domain Context
CATH Clusters
| Superfamily | Peptidase S8/S53 domain |
| Functional Family |
Enzyme Information
| 3.4.21.66 |
Thermitase.
based on mapping to UniProt P04072
Hydrolysis of proteins, including collagen.
-!- From Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate. -!- The N-terminal extension of the polypeptide chain relative to subtilisin contributes to calcium-binding and the high thermostability. -!- The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus are closely similar. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.4.16.
|
UniProtKB Entries (2)
| P04072 |
THET_THEVU
Thermoactinomyces vulgaris
Thermitase
|
| P01051 |
ICIC_HIRME
Hirudo medicinalis
Eglin C
|
PDB Structure
| PDB | 3TEC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Calcium binding to thermitase. Crystallographic studies of thermitase at 0, 5, and 100 mM calcium.
J.Biol.Chem.
|