CATH Domain 3sxsA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P51813

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P51813

BMX_HUMAN

Homo sapiens

Cytoplasmic tyrosine-protein kinase BMX

PDB Structure

PDB	3SXS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase. Muckelbauer, J., Sack, J.S., Ahmed, N., Burke, J., Chang, C.Y., Gao, M., Tino, J., Xie, D., Tebben, A.J. Chem.Biol.Drug Des.