×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1050.30
Functional Family Mycinamicin VI 2''-O-methyltransferase

Enzyme Information

2.1.1.238
Mycinamicin VI 2''-O-methyltransferase.
based on mapping to UniProt Q83WF2
S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III.
-!- The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. -!- Requires Mg(2+) for optimal activity.

UniProtKB Entries (1)

Q83WF2
MYCE_MICGR
Micromonospora griseorubida
Mycinamicin VI 2''-O-methyltransferase

PDB Structure

PDB 3SSN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.
Akey, D.L., Li, S., Konwerski, J.R., Confer, L.A., Bernard, S.M., Anzai, Y., Kato, F., Sherman, D.H., Smith, J.L.
J.Mol.Biol.
CATH-Gene3D is a Global Biodata Core Resource Learn more...