CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1 |
Enzyme Information
| 4.1.3.16 |
4-hydroxy-2-oxoglutarate aldolase.
based on mapping to UniProt Q86XE5
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
-!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.
|
UniProtKB Entries (1)
| Q86XE5 |
HOGA1_HUMAN
Homo sapiens
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
|
PDB Structure
| PDB | 3S5N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria.
Plos One
|
