CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.300 | GMP Synthetase; Chain A, domain 3 |
|
3.30.300.30 | ANL, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.300.30 |
| Functional Family | 2,3-dihydroxybenzoate-AMP ligase |
Enzyme Information
| 6.2.1.3 |
Long-chain-fatty-acid--CoA ligase.
based on mapping to UniProt P9WQ37
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
-!- Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. -!- The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).
|
UniProtKB Entries (1)
| P9WQ37 |
FAC13_MYCTU
Mycobacterium tuberculosis H37Rv
Long-chain-fatty-acid--CoA ligase FadD13
|
PDB Structure
| PDB | 3R44 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: Structural Basis for Housing Lipid Substrates Longer than the Enzyme.
Structure
|
