CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.555 | Phosphatidylinositol 3-kinase; Chain A |
|
1.10.555.10 | Rho GTPase activation protein |
Domain Context
CATH Clusters
| Superfamily | Rho GTPase activation protein |
| Functional Family | Putative inositol polyphosphate 5-phosphatase OCRL-1 |
Enzyme Information
| 3.1.3.36 |
Phosphoinositide 5-phosphatase.
based on mapping to UniProt Q01968
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate.
-!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4). -!- They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed. -!- They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. -!- All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.
|
UniProtKB Entries (1)
| Q01968 |
OCRL_HUMAN
Homo sapiens
Inositol polyphosphate 5-phosphatase OCRL-1
|
PDB Structure
| PDB | 3QIS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Recognition of the F&H motif by the Lowe syndrome protein OCRL.
Nat.Struct.Mol.Biol.
|