CATH Domain 3q90A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.450	Nuclear Transport Factor 2; Chain: A,
	3.10.450.50

Domain Context

CATH Clusters

Superfamily	3.10.450.50
Functional Family	Ras GTPase-activating protein-binding protein 2 isoform 1

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt Q13283

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

3.6.4.13

RNA helicase.

based on mapping to UniProt Q13283

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q13283

G3BP1_HUMAN

Homo sapiens

Ras GTPase-activating protein-binding protein 1

PDB Structure

PDB	3Q90
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1 Welin, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P. To be Published