CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | DNA (cytosine-5)-methyltransferase |
Enzyme Information
| 2.1.1.37 |
DNA (cytosine-5-)-methyltransferase.
based on mapping to UniProt P26358
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
-!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/ -!- Formerly EC 2.1.1.73.
|
UniProtKB Entries (1)
| P26358 |
DNMT1_HUMAN
Homo sapiens
DNA (cytosine-5)-methyltransferase 1
|
PDB Structure
| PDB | 3PTA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.
Science
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