CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 3PMH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.
Zarpellon, A., Celikel, R., Roberts, J.R., McClintock, R.A., Mendolicchio, G.L., Moore, K.L., Jing, H., Varughese, K.I., Ruggeri, Z.M.
Proc.Natl.Acad.Sci.USA
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