CATH Domain 3pfyA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.90

Domain Context

CATH Clusters

Superfamily	3.30.200.90
Functional Family

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt Q96G74

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q96G74

OTUD5_HUMAN

Homo sapiens

OTU domain-containing protein 5

PDB Structure

PDB	3PFY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The catalytic domain of human OTUD5 Walker, J.R., Asinas, A.E., Crombet, L., Dong, A., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Dhe-Paganon, S., Structural Genomics Consortium (SGC) To be Published