CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 12

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q9Y2R2
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

O75563
SKAP2_HUMAN
Homo sapiens
Src kinase-associated phosphoprotein 2

PDB Structure

PDB 3OMH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate.
Yu, X., Chen, M., Zhang, S., Yu, Z.H., Sun, J.P., Wang, L., Liu, S., Imasaki, T., Takagi, Y., Zhang, Z.Y.
J.Biol.Chem.