CATH Domain 3ohfB02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Beta-secretase 1

Enzyme Information

3.4.23.46

Memapsin 2.

based on mapping to UniProt P56817

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817

BACE1_HUMAN

Homo sapiens

Beta-secretase 1

PDB Structure

PDB	3OHF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1. Marcin, L.R., Higgins, M.A., Zusi, F.C., Zhang, Y., Dee, M.F., Parker, M.F., Muckelbauer, J.K., Camac, D.M., Morin, P.E., Ramamurthy, V., Tebben, A.J., Lentz, K.A., Grace, J.E., Marcinkeviciene, J.A., Kopcho, L.M., Burton, C.R., Barten, D.M., Toyn, J.H., Meredith, J.E., Albright, C.F., Bronson, J.J., Macor, J.E., Thompson, L.A. Bioorg.Med.Chem.Lett.