CATH Domain 3ntyA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.100	NADP-dependent oxidoreductase domain

Domain Context

CATH Clusters

Superfamily	NADP-dependent oxidoreductase domain
Functional Family	Aldo-keto reductase family 1 member C3

Enzyme Information

1.3.1.20	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. based on mapping to UniProt Q04828 Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
1.1.1.-	With NAD(+) or NADP(+) as acceptor. based on mapping to UniProt Q04828
1.1.1.149	20-alpha-hydroxysteroid dehydrogenase. based on mapping to UniProt Q04828 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H. -!- Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
1.1.1.112	Indanol dehydrogenase. based on mapping to UniProt Q04828 Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H. -!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.

UniProtKB Entries (1)

AK1C1_HUMAN

Homo sapiens

Aldo-keto reductase family 1 member C1

PDB Structure

PDB	3NTY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis El-Kabbani, O., Dhagat, U., Soda, M., Endo, S., Matsunaga, T., Hara, A. Bioorg.Med.Chem.Lett.