CATH Domain 3nj4D02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Adenosylhomocysteinase

Enzyme Information

3.3.1.1

Adenosylhomocysteinase.

based on mapping to UniProt P23526

S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.

-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P23526

SAHH_HUMAN

Homo sapiens

Adenosylhomocysteinase

PDB Structure

PDB	3NJ4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues. Lee, K.M., Choi, W.J., Lee, Y., Lee, H.J., Zhao, L.X., Lee, H.W., Park, J.G., Kim, H.O., Hwang, K.Y., Heo, Y.S., Choi, S., Jeong, L.S. J.Med.Chem.