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1 keywords

CATH Domain 3ndcA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.950 Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
Homologous Superfamily 3.30.950.10 Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2

Domain Context

CATH Clusters

Superfamily Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
Functional Family

Enzyme Information

2.1.1.133
Precorrin-4 C(11)-methyltransferase.
based on mapping to UniProt O68100
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5.
-!- In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. -!- The first of the four steps is carried out by EC 1.14.13.83 (CobG), yielding precorrin-3B as the product. -!- This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin- 4, precorrin-5 and precorrin-6A, respectively.

UniProtKB Entries (1)

O68100
COBM_RHOCB
Rhodobacter capsulatus SB 1003
Precorrin-4 C(11)-methyltransferase

PDB Structure

PDB 3NDC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Precorrin-4 C11-methyltransferase from Rhodobacter capsulatus
Seyedarabi, A., Pickersgill, R.W.
To be Published
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