CATH Domain 3n5hF00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Farnesyl pyrophosphate synthase

Enzyme Information

2.5.1.1	Dimethylallyltranstransferase. based on mapping to UniProt P14324 Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. -!- Will not accept larger prenyl diphosphates as efficient donors.
2.5.1.10	(2E,6E)-farnesyl diphosphate synthase. based on mapping to UniProt P14324 Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate. -!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

FPPS_HUMAN

Homo sapiens

Farnesyl pyrophosphate synthase

PDB Structure

PDB	3N5H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Jahnke, W., Rondeau, J.M., Cotesta, S., Marzinzik, A., Pelle, X., Geiser, M., Strauss, A., Gotte, M., Bitsch, F., Hemmig, R., Henry, C., Lehmann, S., Glickman, J.F., Roddy, T.P., Stout, S.J., Green, J.R. Nat.Chem.Biol.