CATH Domain 3m6fA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.410	von Willebrand factor, type A domain

Domain Context

CATH Clusters

Superfamily	von Willebrand factor, type A domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

ITAL_HUMAN

Homo sapiens

Integrin alpha-L

PDB Structure

PDB	3M6F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). Watterson, S.H., Xiao, Z., Dodd, D.S., Tortolani, D.R., Vaccaro, W., Potin, D., Launay, M., Stetsko, D.K., Skala, S., Davis, P.M., Lee, D., Yang, X., McIntyre, K.W., Balimane, P., Patel, K., Yang, Z., Marathe, P., Kadiyala, P., Tebben, A.J., Sheriff, S., Chang, C.Y., Ziemba, T., Zhang, H., Chen, B.C., DelMonte, A.J., Aranibar, N., McKinnon, M., Barrish, J.C., Suchard, S.J., Murali Dhar, T.G. J.Med.Chem.