CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.450 | Beta-Lactamase |
|
3.30.450.40 | GAF domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.450.40 |
| Functional Family | Phosphodiesterase |
Enzyme Information
| 3.1.4.35 |
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76074
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
|
UniProtKB Entries (1)
| O76074 |
PDE5A_HUMAN
Homo sapiens
CGMP-specific 3',5'-cyclic phosphodiesterase
|
PDB Structure
| PDB | 3LFV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
J.Biol.Chem.
|
