CATH Domain 3jwqB00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.35	3',5'-cyclic-GMP phosphodiesterase. based on mapping to UniProt O76074 Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
3.1.4.35	3',5'-cyclic-GMP phosphodiesterase. based on mapping to UniProt P51160 Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

PDE6C_HUMAN

Homo sapiens

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

PDB Structure

PDB	3JWQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit Barren, B., Gakhar, L., Muradov, H., Boyd, K.K., Ramaswamy, S., Artemyev, N.O. Embo J.