CATH Domain 3jsgA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.429	Macrophage Migration Inhibitory Factor
	3.30.429.10	Macrophage Migration Inhibitory Factor

Domain Context

CATH Clusters

Superfamily	Macrophage Migration Inhibitory Factor
Functional Family	Macrophage migration inhibitory factor

Enzyme Information

5.3.3.12	L-dopachrome isomerase. based on mapping to UniProt P14174 L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. -!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
5.3.2.1	Phenylpyruvate tautomerase. based on mapping to UniProt P14174 Keto-phenylpyruvate = enol-phenylpyruvate. -!- Also acts on other arylpyruvates.

UniProtKB Entries (1)

MIF_HUMAN

Homo sapiens

Macrophage migration inhibitory factor

PDB Structure

PDB	3JSG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. McLean, L.R., Zhang, Y., Li, H., Li, Z., Lukasczyk, U., Choi, Y.M., Han, Z., Prisco, J., Fordham, J., Tsay, J.T., Reiling, S., Vaz, R.J., Li, Y. Bioorg.Med.Chem.Lett.