CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.8 | Helicase, Ruva Protein; domain 3 |
|
1.10.8.960 |
Domain Context
CATH Clusters
| Superfamily | 1.10.8.960 |
| Functional Family | Glutamate--cysteine ligase |
Enzyme Information
| 6.3.2.2 |
Glutamate--cysteine ligase.
based on mapping to UniProt P32477
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L- cysteine.
-!- Can use L-aminohexanoate in place of glutamate.
|
UniProtKB Entries (1)
| P32477 |
GSH1_YEAST
Saccharomyces cerevisiae S288C
Glutamate--cysteine ligase
|
PDB Structure
| PDB | 3IG8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase.
J.Biol.Chem.
|