CATH Domain 3hyfA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

3.1.26.4

Ribonuclease H.

based on mapping to UniProt P0A7Y4

Endonucleolytic cleavage to 5'-phosphomonoester.

-!- Acts on RNA-DNA hybrids.

UniProtKB Entries (2)

Q72547	Q72547_9HIV1 Human immunodeficiency virus 1 Reverse transcriptase/RNaseH
P0A7Y4	RNH_ECOLI Escherichia coli K-12 Ribonuclease HI

PDB Structure

PDB	3HYF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. Kirschberg, T.A., Balakrishnan, M., Squires, N.H., Barnes, T., Brendza, K.M., Chen, X., Eisenberg, E.J., Jin, W., Kutty, N., Leavitt, S., Liclican, A., Liu, Q., Liu, X., Mak, J., Perry, J.K., Wang, M., Watkins, W.J., Lansdon, E.B. J.Med.Chem.