CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10420 | NagB/RpiA/CoA transferase-like |
Domain Context
CATH Clusters
| Superfamily | NagB/RpiA/CoA transferase-like |
| Functional Family | 5-formyltetrahydrofolate cyclo-ligase |
Enzyme Information
| 6.3.3.2 |
5-formyltetrahydrofolate cyclo-ligase.
based on mapping to UniProt P49914
ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10- methenyltetrahydrofolate.
|
UniProtKB Entries (1)
| P49914 |
MTHFS_HUMAN
Homo sapiens
5-formyltetrahydrofolate cyclo-ligase
|
PDB Structure
| PDB | 3HY4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues
Cancer Res.
|
