CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | Diacylglycerol acyltransferase/mycolyltransferase Ag85C |
Enzyme Information
| 2.3.1.122 |
Trehalose O-mycolyltransferase.
based on mapping to UniProt P9WQN9
2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate.
-!- Catalyzes the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. -!- Trehalose 6-palmitate can also act as donor.
|
| 2.3.1.20 |
Diacylglycerol O-acyltransferase.
based on mapping to UniProt P9WQN9
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
-!- Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
|
UniProtKB Entries (1)
| P9WQN9 |
A85C_MYCTU
Mycobacterium tuberculosis H37Rv
Diacylglycerol acyltransferase/mycolyltransferase Ag85C
|
PDB Structure
| PDB | 3HRH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C.
Mol Biosyst
|