1 keywords

CATH Domain 3gr4D01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.1380 Pyruvate Kinase; Chain: A, domain 1
Homologous Superfamily 3.40.1380.20 Pyruvate kinase, C-terminal domain

Domain Context

CATH Clusters

Superfamily Pyruvate kinase, C-terminal domain
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P14618
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P14618
KPYM_HUMAN
Homo sapiens
Pyruvate kinase PKM

PDB Structure

PDB 3GR4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Activator-Bound Structures of Human Pyruvate Kinase M2
Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H.
to be published